What is COMBINERV®?

COMBINERV® is a food supplement based on Alpha Lipoic Acid M.A.T.R.I.S.® Retard, Superoxide Dismutase GliSODin®, N-Acetyl-L-Carnitine and Vitamin B12 (100% RDA).  

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ALPHA-LIPOIC ACID M.A.T.R.I.S.® RETARD

Endogenous antioxidant which protects cells (especially nerve cells) from damage induced by free radicals (ROS). The patented M.A.T.R.I.S.® Retard formulation allows a slow and controlled release of the Alpha Lipoic Acid, ensuring faster absorption and greater bioavailability.

SUPEROXIDE DISMUTASE GliSODin®

Another endogenous enzyme with antioxidant action. It is the body’s first line of defense against damage induced by free radicals (ROS). GliSODin® is a patented product containing vegetable origin Superoxide dismutase (SOD) encapsulated with the Gliadin protein, which allows the passage gastric without undergoing degradation, and the achievement of the gut where it begins its biological activity.

N-ACETYL-L-CARNITINE

Small endogenous molecule derived from L-carnitine acetylation process. Several studies have demonstrated two important roles of NALC in the organism: it acts as a neuroprotective factor, protecting nerve cells from damage induced by free radicals (ROS), and as a neurotrophic factor, favoring the reparative processes of the nerve.

VITAMIN B12 (100% RDA)

Adequate amounts of Vitamin B12 are essential for the maintenance of myelin, the protective coating around nerves of the peripheral nervous system. This sheath allows electrical impulses to transmit quickly and efficiently along the nerve cells  (Vitamin B12 supports the normal function of the nervous system).

What is COMBINERV®?

COMBINERV® is a food supplement based on Alpha Lipoic Acid M.A.T.R.I.S.® Retard, Superoxide Dismutase GliSODin®, N-Acetyl-L-Carnitine and Vitamin B12 (100% RDA).  

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ALPHA-LIPOIC ACID M.A.T.R.I.S.® RETARD

Endogenous antioxidant which protects cells (especially nerve cells) from damage induced by free radicals (ROS). The patented M.A.T.R.I.S.® Retard formulation allows a slow and controlled release of the Alpha Lipoic Acid, ensuring faster absorption and greater bioavailability.

SUPEROXIDE DISMUTASE GliSODin®

another endogenous enzyme with antioxidant action. It is the body’s first line of defense against damage induced by free radicals (ROS). GliSODin® is a patented product containing vegetable origin Superoxide dismutase (SOD) encapsulated with the Gliadin protein, which allows the passage gastric without undergoing degradation, and the achievement of the gut where it begins its biological activity.

N-ACETYL-L-CARNITINE

Small endogenous molecule derived from L-carnitine acetylation process. Several studies have demonstrated two important roles of NALC in the organism: it acts as a neuroprotective factor, protecting nerve cells from damage induced by free radicals (ROS), and as a neurotrophic factor, favoring the reparative processes of the nerve.

VITAMIN B12 (100% RDA)

Adequate amounts of Vitamin B12 are essential for the maintenance of myelin, the protective coating around nerves of the peripheral nervous system. This sheath allows electrical impulses to transmit quickly and efficiently along the nerve cells  (Vitamin B12 supports the normal function of the nervous system).

2 PATENTS IN ONE PRODUCT

*Technical Data Sheet ‐ α‐Lipoic Acid – M.A.T.R.I.S.® Fast ‐ Retard

Standard Alpha Lipoic Acid has a very short half-life (10- 30 minutes) with 25% bioavailability of the administered dose.

The Alpha-Lipoic Acid present in CombiNERV® is formulated in a delayed-release matrix (M.A.T.R.I.S.® Retard) which guarantees the absorption of over 85% of the active principle within 8 hours.

Using a medium with the same conditions of the gastric environment, the scientists sampled levels of SOD over time. The antioxidant activity of free SOD was destroyed within about 10 minutes. However, when SOD was protected by Gliadin, its enzymatic activity was preserved. The enzyme was released after about 30 minutes, reaching maximum of its activity after 80 – 100 minutes.

*Vouldoukis I., Conti M., Krauss P., Kamaté C., Blazquez S., Tefit M., Mazier D., Calenda A., Dugas B., “Supplementation with gliadin-combined plant superoxide dismutase extract promotes antioxidant defences and protects against oxidative stress” Phytotherapy Research 2004, Volume 18, Pages 957-962.

Using a medium with the same conditions of the gastric environment, the scientists sampled levels of SOD over time. The antioxidant activity of free SOD was destroyed within about 10 minutes. However, when SOD was protected by Gliadin, its enzymatic activity was preserved. The enzyme was released after about 30 minutes, reaching maximum of its activity after 80 – 100 minutes.

Scientific evidence has demonstrated the potential beneficial effects of the active principles contained in CombiNERV® in case of:

Scientific evidence has demonstrated the potential beneficial effects of the active principles contained in CombiNERV® in case of:

DIABETIC NEUROPATHY

RADICULOPATHIES

(Cervical, Lubar, etc…)

CANALICULAR SYNDROMES

(Carpal, Ulnarian, Cubital tunnel syndrome)

DIABETIC NEUROPATHY

RADICULOPATHIES

(Cervical, Lumbar, etc…)

CANALICULAR SYNDROMES

(Carpal, Ulnarian, Cubital tunnel syndrome)

DRUG INDUCED NEUROPATHIES

(caused by some anticancer drugs)

NEURALGIA

(Trigeminal Neuralgia, Post-herpetic neuralgia)

TINNITUS AND DIZZINESS

(Neuro-inflammatory causes)

DRUG INDUCED NEUROPATHIES

(caused by some anticancer drugs)

NEURALGIA

(Trigeminal Neuralgia, Post-herpetic neuralgia)

TINNITUS AND DIZZINESS

(Neuro-inflammatory causes)

COMBINERV® AND DIABETIC NEUROPATHY:
SCIENTIFICALLY DEMONSTRATED EFFICACY  AND SAFETY*

*Didangelos T, Karlafti E, Kotzakioulafi E, Kontoninas Z, Margaritidis C, Giannoulaki P, Kantartzis K. Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B12, and Carnitine for 12 Months in Patients with Diabetic Neuropathy. Nutrients. 2020 Oct 23;12(11):3254. doi: 10.3390/nu12113254. PMID: 33114210; PMCID: PMC7690794.

HOW TO USE

It is recommended to take one tablet a day, regardless of meals.

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INGREDIENTS

M.A.T.R.I.S.® Retard Alpha Lipoic Acid (Alpha Lipoic Acid, Talc, Ethylcellulose), L-Acetyl Carnitine Hydrochloride, Bulking Agent: Microcrystalline Cellulose; Hydroxypropylcellulose, Anti-caking agents: Silicon dioxide, Magnesium salts of fatty acids; Coating agents: Polyvinyl alcohol, Polyethylene glycol, Hydroxypropylmethylcellulose, Talc; Cross-linked sodium carboxymethylcellulose, Glisodin® superoxide dismutase 1 IU / mg (from Cucumis melo L. fruits, maltodextrin, wheat gluten); Vitamin B12 (Cyanocobalamin), Colors: Calcium carbonate, Yellow iron oxide.

WARNING

Keep out of the reach of children under 3. Do not take more than the daily allowance specified on the label. Food supplements must not be considered as a substitute for a varied balanced diet and a healthy lifestyle. Do not use the product if the packet has been opened or is damaged in any way. Use is not recommended in cases of overt hypersensitivity to one or more ingredients contained in the product. Considering the nature of the ingredients the appearance of the product could vary from batch to batch, but this does not imply that the quality is compromised. Consult your doctor or GP before taking CombiNERV®. In rare cases lipoic acid can cause hypoglycaemia.

PACKET CONTENTS

20 coated tablets

FAQ

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HOW TO TAKE CombiNERV?

It is recommended to take one tablet a day, regardless of meals. You can take CombiNERV® any time of the day, without compromising its effectiveness.

FOR HOW LONG CAN COMBINERV BE TAKEN?

It is recommended to take CombiNERV® for at least two consecutive months for better efficacy and long-term results.

ARE THERE ANY SIDE EFFECTS?

Do not take CombiNERV® in case of overt hypersensitivity to one or more ingredients or any other component of this food supplement.
Do not take during pregnancy and lactation.
Do not administer to children under the age of 12.
Contains GLUTEN: product unsuited for patients with celiac disease. In rare cases lipoic acid can cause hypoglycaemia.

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IS A DOCTOR'S PRESCRIPTION REQUIRED?

CombiNERV® is a food supplement therefore a prescription is not required.

CAN CombiNERV BE TAKEN WITH OTHER DRUGS?

CombiNERV® can be taken with other drugs without any side effects.

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HOW TO TAKE CombiNERV?

It is recommended to take one tablet a day, regardless of meals. You can take CombiNERV® any time of the day, without compromising its effectiveness.

FOR HOW LONG CAN COMBINERV BE TAKEN?

It is recommended to take CombiNERV® for at least two consecutive months for better efficacy and long-term results.

ARE THERE ANY SIDE EFFECTS?

Do not take CombiNERV® in case of overt hypersensitivity to one or more ingredients or any other component of this food supplement.
Do not take during pregnancy and lactation.
Do not administer to children under the age of 12.
Contains GLUTEN: product unsuited for patients with celiac disease. In rare cases lipoic acid can cause hypoglycaemia.

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IS A DOCTOR'S PRESCRIPTION REQUIRED?

CombiNERV® is a food supplement therefore a prescription is not required.

CAN CombiNERV BE TAKEN WITH OTHER DRUGS?

CombiNERV® can be taken with other drugs without any side effects.

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